Why PRP fails in certain people

Platelet-rich plasma (PRP) therapy is a treatment that uses a patient's own blood components to promote healing, particularly in musculoskeletal injuries. However, PRP may not be effective for everyone. Here are several reasons why PRP might fail in certain individuals:

1. *Chronicity of the Condition*: PRP is generally more effective for acute injuries. In chronic conditions, the underlying tissue may have undergone irreversible changes, making it less responsive to PRP.

2. *Quality of Platelet Preparation*: The effectiveness of PRP can depend on how it is prepared. Variability in the concentration of platelets and growth factors can influence outcomes. Poor preparation techniques can result in less effective PRP. At Klinik Setia Gemilang, we use double spinning method and very specific technique to produce PRP at highest quality.

3. *Underlying Health Conditions*: Certain medical conditions, such as diabetes, obesity, or autoimmune disorders, can impair healing and reduce the effectiveness of PRP therapy.

4. *Age*: Older individuals may have a reduced regenerative capacity, which can affect the efficacy of PRP treatments.

5. *Inadequate Delivery Method*: The way PRP is injected or applied can influence its effectiveness. If not delivered to the right location or if the technique is poor, it may not provide the intended benefits. The delivery can be aided with ultrasound guidance or C-arm. However, radiation exposure from C-arm may impact the quality of PRP

6. *Patient Expectations and Compliance*: Sometimes, unrealistic expectations regarding the outcomes of PRP therapy can lead to perceived failure. Additionally, not following post-treatment rehabilitation protocols can also hinder recovery. PRP takes time to show the effect.

7. *Infection or Inflammation*: Pre-existing infections or inflammatory conditions can interfere with the healing process and reduce the effectiveness of PRP. Conditions like gouty arthritis primarily affects the joints because of inflammation. PRP being is being a proinflammatory agent may not reverse damage done by gouty arthritis

8. *Medication*: Patient on anti-inflammatory medicines usually finds PRP not effective. Typically they need to avoids such steroids, NSAIDS and blood thinner for at least 1 week before and after administration.

Understanding these factors can help guide discussions between patients and healthcare providers about the potential benefits and limitations of PRP therapy.